The paclitaxel site in tubulin probed by site-directed mutagenesis ofSaccharomyces cerevisiaeβ-tubulin
نویسندگان
چکیده
منابع مشابه
Paclitaxel resistance by random mutagenesis of α-tubulin.
Many mammalian β-tubulin mutations that confer paclitaxel resistance have been characterized, but little is currently known about the role of α-tubulin mutations in drug resistance. Previous studies using two-dimensional gel electrophoresis showed that α-tubulin mutations occur with a frequency equal to β-tubulin mutations among CHO cells selected for resistance to paclitaxel but the identities...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 2008
ISSN: 0014-5793
DOI: 10.1016/j.febslet.2008.06.013